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How many people in the world smoke cannabis? The UN estimates there is somewhere between 128 and 232 million people in the world who have tried cannabis on at least one occasion. That’s somewhere between 2.7% and 4.9% of the world population. The authors also point out that there is currently no global data on how many people have tried cannabis purely for medicinal purposes or as prescribed by a physician, but data in the United States suggests that one in roughly 7-8 cannabis users has used marijuana medicinally. The authors also point to an increased use in the last several decades of resin-based cannabis products as well as synthetic cannabinoids.